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Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer’s disease risk in the general population: a Mendelian randomization study

2022-04-12

Abstract excerpt

<h4>Aims/hypothesis</h4> Metformin use has been associated with reduced incident dementia in diabetic patients in observational studies. However, the causality between the two in the general population is unclear. This study uses Mendelian randomization (MR) to investigate the causal effect of metformin targets on Alzheimer’s disease (AD) and potential causal mechanisms in the brain linking the two. <h4>Methods</h...

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Literature Corpus work
bbff38f9-6b83-52f8-afce-dd3320c9cc2d
DOI
10.1101/2022.04.09.22273625
Open publication

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Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer’s disease risk in the general population: a Mendelian randomization studyDOI 10.1101/2022.04.09.22273625
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