Article

Drug repurposing of metformin for Alzheimer’s disease: Combining causal inference in medical records data and systems pharmacology for biomarker identification

2021-08-12

Abstract excerpt

<h4>ABSTRACT</h4> Metformin, an antidiabetic drug, triggers anti-aging cellular responses. Aging is the principal risk factor for dementia, but previous observational studies of the diabetes drugs metformin vs. sulfonylureas have been mixed. We tested the hypotheses that metformin improves survival and reduces the risk of dementia, relative to the sulfonylureas, by emulating target trials in electronic health reco...

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Literature Corpus work: 8834398b-81a6-5192-92bf-9755a4d95cf1
DOI: 10.1101/2021.08.10.21261747

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