Article
Mendelian randomization study of diabetes and dementia in the Million Veteran Program.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Oct 2023
Litkowski Elizabeth M, Logue Mark W, Zhang Rui, Charest Brian R, Lange Ethan M, Hokanson John E, Lynch Julie A, Vujkovic Marijana, Phillips Lawrence S, Hauger Richard L, Lange Leslie A, Raghavan Sridharan
Abstract excerpt
INTRODUCTION: Diabetes and dementia are diseases of high health-care burden worldwide. Individuals with diabetes have 1.4 to 2.2 times higher risk of dementia. Our objective was to evaluate evidence of causality between these two common diseases. METHODS: We conducted a one-sample Mendelian randomization (MR) analysis in the US Department of Veterans Affairs Million Veteran program. The study included 334,672...
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