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Adenocarcinoma-neuroendocrine transition of androgen resistant PCa depends on SPARC down-regulation in stromal accessory cells

2020-01-01

Abstract excerpt

Adenocarcinoma-neuroendocrine differentiation of castration resistant prostate cancer often occurs in a relevant subset of patients as a mechanism of resistance to androgen deprivation and androgen-receptor targeted drugs. Tumor cell plasticity toward neuroendocrine differentiation can be sustained by signals provided by the tumour microenvironment. The matricellular protein SPARC is a crucial modulator of cancer...

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Literature Corpus work
bbf6e999-a9c6-5604-8251-2e71cbf2b963
DOI
10.21954/ou.ro.00010fec
Open publication

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