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Article

SYNERGxDB: an integrative pharmacogenomic portal to identify synergistic drug combinations for precision oncology.

Nucleic acids research - 2 Jul 2020

Seo Heewon, Tkachuk Denis, Ho Chantal, Mammoliti Anthony, Rezaie Aria, Madani Tonekaboni Seyed Ali, Haibe-Kains Benjamin

Abstract excerpt

Drug-combination data portals have recently been introduced to mine huge amounts of pharmacological data with the aim of improving current chemotherapy strategies. However, these portals have only been investigated for isolated datasets, and molecular profiles of cancer cell lines are lacking. Here we developed a cloud-based pharmacogenomics portal called SYNERGxDB (http://SYNERGxDB.ca/) that integrates multiple...

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Identifiers

PMID: 32442307
DOI: 10.1093/nar/gkaa421
PMCID: PMC7319572

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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