Article

Molecular Basis of Antibiotic Self-Resistance in a Bee Larvae Pathogen

2021-11-23

Abstract excerpt

Paenibacillus larvae , the causative agent of the devastating honey-bee disease American Foulbrood, produces the cationic polyketide-peptide hybrid paenilamicin that displays high antibacterial and antifungal activity. Its biosynthetic gene cluster contains a gene coding for the N -acetyltransferase PamZ. We show that PamZ acts as self-resistance factor in P. larvae by deactivation of paenilamicin. Using tandem...

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Literature Corpus work: bbd8ae3d-a36c-51b1-bdd9-75b2ac4f356a
DOI: 10.1101/2021.11.23.469742

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