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Article

Structural analysis and biosynthetic engineering of a solubility-improved and less-hemolytic nystatin-like polyene in Pseudonocardia autotrophica.

Applied microbiology and biotechnology - 1 Jul 2012

Lee Mi-Jin, Kong Dekun, Han Kyuboem, Sherman David H, Bai Linquan, Deng Zixin, Lin Shuangjun, Kim Eung-Soo

Abstract excerpt

Polyene antibiotics such as nystatin are a large family of very valuable antifungal polyketide compounds typically produced by soil actinomycetes. Previously, using a polyene cytochrome P450 hydroxylase-specific genome screening strategy, Pseudonocardia autotrophica KCTC9441 was determined to contain an approximately 125.7-kb region of contiguous DNA with a total of 23 open reading frames, which are involved in...

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PMID: 22382166
DOI: 10.1007/s00253-012-3955-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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