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Article

Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis.

Proceedings of the National Academy of Sciences of the United States of America - 6 Aug 2013

Lee Jaeheon, Hao Yue, Blair Patricia M, Melby Joel O, Agarwal Vinayak, Burkhart Brandon J, Nair Satish K, Mitchell Douglas A

Abstract excerpt

Plantazolicin (PZN), a polyheterocyclic, N(α),N(α)-dimethylarginine-containing antibiotic, harbors remarkably specific bactericidal activity toward strains of Bacillus anthracis, the causative agent of anthrax. Previous studies demonstrated that genetic deletion of the S-adenosyl-L-methionine-dependent methyltransferase from the PZN biosynthetic gene cluster results in the formation of desmethylPZN, which is...

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Identifiers

PMID: 23878226
DOI: 10.1073/pnas.1306101110
PMCID: PMC3740862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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