Article

Guanine quadruplexes mediate mitochondrial RNA polymerase pausing

2023-10-19

Abstract excerpt

The information content within nucleic acids extends beyond the primary sequence to include secondary structures with functional roles in cells. Guanine-rich sequences form structures called guanine quadruplexes (G4) that result from non-canonical base pairing between guanine residues. These stable structures are enriched in gene promoters and have been correlated with the locations of RNA polymerase II pausing (P...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bbbefdf8-191b-54ee-9cd9-49392891e3dd
DOI: 10.1101/2023.10.17.562821

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Guanine quadruplexes mediate mitochondrial RNA polymerase pausingDOI 10.1101/2023.10.17.562821Read

Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cellsSemantic proximity Read

Replication and Transcription of Human Mitochondrial DNA.Semantic proximity Read

Regulation and function of the mitochondrial genome.Semantic proximity Read

Nucleic acid sequence determinants of transcriptional pausing by human mitochondrial RNA polymerase (POLRMT)Semantic proximity Read

Rare genetic diseases associated with G-quadruplex-induced replication stress.Semantic proximity Read

Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro.Semantic proximity Read

A competitive formation of DNA:RNA hybrid G-quadruplex is responsible to the mitochondrial transcription termination at the DNA replication priming site.Semantic proximity Read

Replication-induced DNA secondary structures drive fork uncoupling and breakageSemantic proximity Read

Initiation of mtDNA transcription is followed by pausing, and diverges across human cell types and during evolution.Semantic proximity Read

S phase R-loop formation is restricted by PrimPol-mediated reprimingSemantic proximity Read

The control of mitochondrial DNA replication during development and tumorigenesis.Semantic proximity Read

Comparative analysis of mitochondrial genomes in different species reveals the evolution of G-quadruplexesSemantic proximity Read