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Overcoming Antigen Escape and T-Cell Exhaustion in CAR-T Therapy for Leukemia

23 Sept 2024

Abstract excerpt

Leukemia is a prevalent pediatric cancer with significant challenges, particularly in relapsed or refractory cases. Chimeric antigen receptor T-cell (CAR-T) therapy has emerged as a personalized cancer treatment, modifying patients' T cells to target and destroy resistant cancer cells. This study reviews the current therapeutic options of CAR-T therapy for leukemia, addressing the primary obstacles such as...

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PMID: 39329777
DOI: 10.3390/cells13181596

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