Article

The type 1 diabetes candidate genes PTPN2 and BACH2 regulate novel IFN-α-induced crosstalk between the JAK/STAT and MAPKs pathways in human beta cells

2025-03-12

Abstract excerpt

<title>Abstract</title> <p>Type 1 diabetes (T1D) is a chronic autoimmune disease that leads to the progressive loss of pancreatic beta cells. Interferons (IFNs) contribute to the initiation and amplification of beta cell autoimmunity. STAT1 is the main mediator of IFN signalling but little is known on its complex activation processes and role in the progression of beta cell failure. We presently show that two T1D...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bbb75e17-b726-5f50-ab3f-d4c1f370274f
DOI: 10.21203/rs.3.rs-6079043/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The type 1 diabetes candidate genes PTPN2 and BACH2 regulate novel IFN-α-induced crosstalk between the JAK/STAT and MAPKs pathways in human beta cellsDOI 10.21203/rs.3.rs-6079043/v1Read

Pharmacological inhibition of tyrosine protein-kinase 2 reduces islet inflammation and delays type 1 diabetes onset in miceSemantic proximity Read

Cytokine receptor signaling through the Jak–Stat–Socs pathway in diseaseSemantic proximity Read

JAK-STAT Signaling: From Interferons to CytokinesSemantic proximity Read

STAT4 polymorphism is associated with early-onset type 1 diabetes, but not with late-onset type 1 diabetes.Semantic proximity Read

BACH2, a candidate risk gene for type 1 diabetes, regulates apoptosis in pancreatic β-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2.Semantic proximity Read

Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses in autoimmune disordersSemantic proximity Read

Evidence for the role of STAT4 as a general autoimmunity locus in the Korean population.Semantic proximity Read

<i>PTPN2</i>, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein BimSemantic proximity Read

PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.Semantic proximity Read

Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-gamma, but not IFN-alpha, signaling.Semantic proximity Read

TYK2, a Candidate Gene for Type 1 Diabetes, Modulates Apoptosis and the Innate Immune Response in Human Pancreatic β-Cells.Semantic proximity Read

Aberrant cell signalling in PBMCs upon IFN-α stimulation in primary Sjögren's syndrome patients associates with type I interferon signature.Semantic proximity Read