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Article

PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.

Diabetes - 1 Jun 2009

Moore Fabrice, Colli Maikel L, Cnop Miriam, Esteve Mariana Igoillo, Cardozo Alessandra K, Cunha Daniel A, Bugliani Marco, Marchetti Piero, Eizirik Décio L

Abstract excerpt

OBJECTIVE: The pathogenesis of type 1 diabetes has a strong genetic component. Genome-wide association scans recently identified novel susceptibility genes including the phosphatases PTPN22 and PTPN2. We hypothesized that PTPN2 plays a direct role in beta-cell demise and assessed PTPN2 expression...

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Source

Open in PubMed Open full text

Identifiers

PMID: 19336676
DOI: 10.2337/db08-1510
PMCID: PMC2682688

Genes

PTPN2
STAT1
PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19336676-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.PMID 19336676Read ↗

<i>PTPN2</i>, a Candidate Gene for Type 1 Diabetes, Modulates Pancreatic β-Cell Apoptosis via Regulation of the BH3-Only Protein BimSemantic proximity Read ↗

BACH2, a candidate risk gene for type 1 diabetes, regulates apoptosis in pancreatic β-cells via JNK1 modulation and crosstalk with the candidate gene PTPN2.Semantic proximity Read ↗

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SKAP2, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients.Semantic proximity Read ↗

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