Article

MCPH1 inhibits condensin II during interphase by regulating its SMC2-kleisin interface

2021-07-20

Abstract excerpt

<h4>ABSTRACT</h4> The dramatic change in morphology of chromosomal DNAs between interphase and mitosis is one of the defining features of the eukaryotic cell cycle. Two types of enzymes, namely cohesin and condensin confer the topology of chromosomal DNA by extruding DNA loops. While condensin normally configures chromosomes exclusively during mitosis, cohesin does so during interphase. The processivity of cohesi...

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Literature Corpus work: bbabe0c1-d369-5074-932c-852d7fd65ea6
DOI: 10.1101/2021.07.20.453033

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