Article
MCPH1, mutated in primary microcephaly, is required for efficient chromosome alignment during mitosis.
Scientific reports - 12 Oct 2017
Arroyo M, Kuriyama R, Trimborn M, Keifenheim D, Cañuelo A, Sánchez A, Clarke D J, Marchal J A
Abstract excerpt
MCPH1 gene, mutated in primary microcephaly, regulates cell progression into mitosis. While this role has been extensively investigated in the context of DNA damage, its function during unperturbed cell cycles has been given less attention. Here we have analyzed the dynamics of chromosome condensation and cell cycle progression in MCPH1 deficient cells under undamaging conditions. Our study demonstrates that...
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