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Article

Condensin I-mediated mitotic chromosome assembly requires association with chromokinesin KIF4A.

Genes & development - 1 Sept 2016

Takahashi Motoko, Wakai Toshifumi, Hirota Toru

Abstract excerpt

The chromokinesin KIF4A has been implicated in shaping mitotic chromosomes, but its functional relationship to condensin complexes remains controversial. Here, we found that, in mitosis, KIF4A associates with condensin I but not with condensin II. Mutational analyses indicated that the enrichment of condensin I to chromosomal axes depends on its association with KIF4A in a way that likely involves its motor...

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PMID: 27633014
DOI: 10.1101/gad.282855.116
PMCID: PMC5066236

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