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Article

A role for condensin-mediator interaction in mitotic chromosome organization.

Nature communications - 8 Feb 2026

Iwasaki Osamu, Tashiro Sanki, Chung Claire Yik-Lok, Hayashi Tomomi, Tanizawa Hideki, Wang Xuebing, Ohta Shinya, Fujioka Yuko, Han Joseph, Tabor Gabrielle, Kawagoe Mikihiro, Marmorstein Ronen, Noda Nobuo N, Noma Ken-Ichi

Abstract excerpt

Condensin organizes eukaryotic genomes into three-dimensional (3D) chromosome architectures that support accurate chromosome segregation during mitosis. However, the molecular mechanisms underlying this organization remain unclear. Here, we identify a previously unrecognized interaction between the condensin subunit Cnd1 and the mediator subunit Pmc4 in fission yeast, Schizosaccharomyces pombe. We characterize a...

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Identifiers

PMID: 41654523
DOI: 10.1038/s41467-026-69270-x
PMCID: PMC12996288

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