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Article

Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi syndrome.

Neurobiology of disease - 1 Aug 2010

Morabito Michael V, Abbas Atheir I, Hood Jennifer L, Kesterson Robert A, Jacobs Michelle M, Kump David S, Hachey David L, Roth Bryan L, Emeson Ronald B

Abstract excerpt

RNA transcripts encoding the 2C-subtype of serotonin (5HT(2C)) receptor undergo up to five adenosine-to-inosine editing events to encode twenty-four protein isoforms. To examine the effects of altered 5HT(2C) editing in vivo, we generated mutant mice solely expressing the fully-edited (VGV) isoform of the receptor. Mutant animals present phenotypic characteristics of Prader-Willi syndrome (PWS) including a...

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Identifiers

PMID: 20394819
DOI: 10.1016/j.nbd.2010.04.004
PMCID: PMC2906772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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