Article

Prime editing of the β <sub>1</sub> adrenoceptor in the brain reprograms mouse behavior

2023-05-19

Abstract excerpt

<h4>Summary</h4> Prime editing is a highly versatile genome editing technology that holds great potential for treating genetic diseases 1, 2 . While in vivo prime editing has recently been conducted in the brain, liver, heart, and retina 3–6 , application of this technology to modulate neural circuits in the brain has not been reported yet. Here, we employ adeno-associated viral vectors to deliver optimized in...

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Literature Corpus work: b580bbdc-b439-5e64-8013-7a640917d503
DOI: 10.1101/2023.05.19.541410

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