Article

Atomistic molecular simulations of A <i>β</i> -Zn conformational ensembles

2023-03-25

Abstract excerpt

The amyloid-forming A β peptide is able to interact with metal cations to form very stable complexes that influence fibril formation and contribute to the onset of Alzheimer’s disease. Multiple structures of peptides derived from A β in complex with different metals have been resolved experimentally to provide an atomic-level description of the metal-protein interactions. However, A β is intrinsically disordere...

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Identifiers and source

Literature Corpus work: bb78a718-6215-549f-9d17-e8f9d444a453
DOI: 10.1101/2023.03.23.534009

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