Article
Dual effects of familial Alzheimer's disease mutations (D7H, D7N, and H6R) on amyloid β peptide: correlation dynamics and zinc binding.
Proteins - 1 Dec 2014
Xu Liang, Chen Yonggang, Wang Xiaojuan
Abstract excerpt
Although the N-terminal region of Amyloid β (Aβ) peptides plays dual roles as metal-coordinating sites and conformational modulator, few studies have been performed to explore the effects of mutations at this region on the overall conformational ensemble of Aβ and the binding propensity of metal ions. In this work, we focus on how three familial Alzheimer's disease mutations (D7H, D7N, and H6R) alter the...
Topics
- Alzheimer Disease
- Amino Acid Substitution
- Amyloid beta-Peptides
- Amyloid beta-Protein Precursor
- Binding Sites
- Energy Transfer
- Humans
- Hydrophobic and Hydrophilic Interactions
- Kinetics
- Models, Molecular
- Molecular Dynamics Simulation