Article

Innate immune signaling drives late cardiac toxicity following DNA damaging cancer therapies

2021-09-26

Abstract excerpt

Late cardiac toxicity is a potentially lethal complication of cancer therapy, yet the pathogenic mechanism remains largely unknown, and few treatment options exist. Here we report DNA damaging agents such as radiation and anthracycline chemotherapies induce delayed cardiac inflammation following therapy due to activation of cGAS and STING-dependent type I interferon signaling. Genetic ablation of cGAS-STING-signal...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bb473bf3-ed26-5f50-bf7c-1ab6e2979a13
DOI: 10.1101/2021.09.26.461865

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Innate immune signaling drives late cardiac toxicity following DNA damaging cancer therapiesDOI 10.1101/2021.09.26.461865Read

Inhibit of the cGAS-STING-STAT1 pathway protects heart from the Doxorubicin-induced cardiotoxicitySemantic proximity Read

STING enhances cell death through regulation of reactive oxygen species and DNA damageSemantic proximity Read

STING promotes homeostatic maintenance of tissues and confers longevity with agingSemantic proximity Read

Interferon- and STING-independent induction of type I interferon stimulated genes during fractionated irradiationSemantic proximity Read

The cGAS/STING Pathway: Friend or Foe in Regulating CardiomyopathySemantic proximity Read

Conventional DNA-Damaging Cancer Therapies and Emerging cGAS-STING Activation: A Review and Perspectives Regarding Immunotherapeutic PotentialSemantic proximity Read

Senescence and inflammation are unintended adverse consequences of CRISPR-Cas9/AAV6-mediated gene editing in hematopoietic stem cellsSemantic proximity Read

Targeting cGAS-STING signaling and cell death modes in cancer and autoimmune diseasesSemantic proximity Read

Targeting DNA damage response in cardiovascular diseases: from pathophysiology to therapeutic implicationsSemantic proximity Read

Pharmacological Targeting of STING-Dependent IL-6 Production in Cancer CellsSemantic proximity Read

A Comprehensive Review of Circular RNAs in Cancer Therapy-Induced CardiotoxicitySemantic proximity Read

Emerging mitochondrial signaling mechanisms in cardio-oncology: beyond oxidative stressSemantic proximity Read