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Article

Interferon- and STING-independent induction of type I interferon stimulated genes during fractionated irradiation

8 May 2021

Abstract excerpt

BACKGROUND: Improvement of radiotherapy efficacy requires better insight in the dynamic responses that occur during irradiation. Here, we aimed to identify the molecular responses that are triggered during clinically applied fractionated irradiation. METHODS: Gene expression analysis was performed by RNAseq or microarray analysis of cancer cells or xenograft tumors, respectively, subjected to 3-5 weeks of 5 × 2...

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PMID: 33964942
DOI: 10.1186/s13046-021-01962-2

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