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Targeting DNA damage response in cardiovascular diseases: from pathophysiology to therapeutic implications

9 May 2022

Abstract excerpt

Cardiovascular diseases (CVDs) arise from a complex interplay among genomic, proteomic, and metabolomic abnormalities. Emerging evidence has recently consolidated the presence of robust DNA damage in a variety of cardiovascular disorders. DNA damage triggers a series of cellular responses termed DNA damage response (DDR) including detection of DNA lesions, cell cycle arrest, DNA repair, cellular senescence, and...

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PMID: 35576480
DOI: 10.1093/cvr/cvac080

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