Article

Inhibit of the cGAS-STING-STAT1 pathway protects heart from the Doxorubicin-induced cardiotoxicity

2024-06-04

Abstract excerpt

<title>Abstract</title> <p>Doxorubicin (DOX) is a common clinical chemotherapeutic drug. However, DOX-induced cardiotoxicity (DIC) limits the wide and long-term clinical use to treat cancers. This study aims to dissect the mechanism in which DNA damage-triggered micronucleus (MN) formation activates the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING)-STAT1 pathway in cardiac fibroblasts duri...

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Literature Corpus work: b43619ee-264b-5437-8dce-06f03a167da0
DOI: 10.21203/rs.3.rs-4253972/v1

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