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Article

Pharmacological Targeting of STING-Dependent IL-6 Production in Cancer Cells

11 Jan 2022

Abstract excerpt

Activation of the STING pathway upon genotoxic treatment of cancer cells has been shown to lead to anti-tumoral effects, mediated through the acute production of interferon (IFN)-β. Conversely, the pathway also correlates with the expression of NF-κB-driven pro-tumorigenic genes, but these associations are only poorly defined in the context of genotoxic treatment, and are thought to correlate with a chronic...

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PMID: 35087822
DOI: 10.3389/fcell.2021.709618

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