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Article

STING enhances cell death through regulation of reactive oxygen species and DNA damage

19 Apr 2021

Abstract excerpt

Resistance to DNA-damaging agents is a significant cause of treatment failure and poor outcomes in oncology. To identify unrecognized regulators of cell survival we performed a whole-genome CRISPR-Cas9 screen using treatment with ionizing radiation as a selective pressure, and identified STING (stimulator of interferon genes) as an intrinsic regulator of tumor cell survival. We show that STING regulates a...

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PMID: 33875663
DOI: 10.1038/s41467-021-22572-8

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