Article

Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer’s disease, restores synapse integrity and memory in a disease mouse model

2024-01-29

Abstract excerpt

Increasing evidence supports a role for deficient Wnt signaling in Alzheimer’s disease (AD). Studies reveal that the secreted Wnt antagonist Dickkopf-3 (DKK3) colocalizes to amyloid plaques in AD patients. Here, we investigate the contribution of DKK3 to synapse integrity in healthy and AD brains. Our findings show that DKK3 expression is upregulated in the brains of AD subjects and that DKK3 protein levels increa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7b987af5-28b1-50d4-a2cd-c5a471522827
DOI: 10.7554/elife.89453.3

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer’s disease, restores synapse integrity and memory in a disease mouse modelDOI 10.7554/elife.89453.3Read

Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer’s disease, restores synapse integrity and memory in a disease mouse modelSemantic proximity Read

Dickkopf 3 (Dkk3) Improves Amyloid-β Pathology, Cognitive Dysfunction, and Cerebral Glucose Metabolism in a Transgenic Mouse Model of Alzheimer's Disease.Semantic proximity Read

The Secreted Wnt Antagonist Dickkopf-1 Is Required for Amyloid β-Mediated Synaptic LossSemantic proximity Read

Reversal of Synapse Degeneration by Restoring Wnt Signaling in the Adult HippocampusSemantic proximity Read

Age- and Sex-Associated Wnt Signaling Dysregulation is Exacerbated from the Early Stages of Neuropathology in an Alzheimer’s Disease ModelSemantic proximity Read

Increased Dickkopf-1 expression in transgenic mouse models of neurodegenerative disease.Semantic proximity Read

The role of GSK3 in Alzheimer diseaseSemantic proximity Read

Dysregulated Wnt and NFAT signaling in a Parkinson's disease LRRK2 G2019S knock-in model.Semantic proximity Read

Dysregulated Wnt and NFAT signaling in a Parkinson’s disease LRRK2 G2019S knock-in modelSemantic proximity Read

Wnt signaling in the nervous system and in Alzheimer's diseaseSemantic proximity Read

Microglial expression of the Wnt signalling modulator <i>DKK2</i> differs between human Alzheimer’s disease brains and mouse neurodegeneration modelsSemantic proximity Read

Tau kinase I overexpression induces dentate gyrus degeneration.Semantic proximity Read