Article

PI3K activation prevents Aβ42-induced synapse loss and favors insoluble amyloid deposits formation

2019-05-24

Abstract excerpt

Alzheimer’s disease is, to a large extent, a disease of the synapse triggered by the unbalanced amyloidogenic cleavage of the amyloid precursor protein APP. Excess of Aβ42 peptide in particular is considered a hallmark of the disease. Here we drive the expression of the human Aβ42 peptide to assay the neuroprotective effects of PI3K in adult Drosophila melanogaster . We show that the neuronal expression of the hu...

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Literature Corpus work: 46e63b5f-2fff-58d4-8ea9-e5a83347242e
DOI: 10.1101/649087

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