Article
Dissecting tumor microenvironment heterogeneity in syngeneic mouse models: insights on cancer-associated fibroblast phenotypes shaped by infiltrating T cells.
Frontiers in immunology - 1 Jan 2023
Carretta Marco, Thorseth Marie-Louise, Schina Aimilia, Agardy Dennis Alexander, Johansen Astrid Zedlitz, Baker Kevin James, Khan Shawez, Rømer Anne Mette Askehøj, Fjæstad Klaire Yixin, Linder Hannes, Kuczek Dorota Ewa, Donia Marco, Grøntved Lars, Madsen Daniel Hargbøl
Abstract excerpt
Murine syngeneic tumor models have been used extensively for cancer research for several decades and have been instrumental in driving the discovery and development of cancer immunotherapies. These tumor models are very simplistic cancer models, but recent reports have, however, indicated that the different inoculated cancer cell lines can lead to the formation of unique tumor microenvironments (TMEs). To gain...
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