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Article

Murine Microenvironment Metaprofiles Associate with Human Cancer Etiology and Intrinsic Subtypes

21 Jan 2013

Abstract excerpt

PURPOSE: Ionizing radiation is a well-established carcinogen in rodent models and a risk factor associated with human cancer. We developed a mouse model that captures radiation effects on host biology by transplanting unirradiated Trp53-null mammary tissue to sham or irradiated hosts. Gene expression profiles of tumors that arose in irradiated mice are distinct from those that arose in naïve hosts. We asked...

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PMID: 23339125
DOI: 10.1158/1078-0432.ccr-12-3554

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