Article

BMP4 reprograms glucose metabolism in hepatocellular carcinoma (HCC) cells by upregulating glycogen synthesis through the SMAD/SLC2A1 (GLUT1) signaling axis

2022-12-15

Abstract excerpt

<h4>Background: </h4> Excessive hepatic glycogen accumulation benefits tumorigenesis and cancer cell survival. We previously reported that BMP4 was elevated in Hepatocellular carcinoma (HCC) and augmented HCC cell survival under hypoxia and hypoglycemia conditions by promoting the glycolysis pathway. However, the mechanism underlying BMP4’s effect on glucose metabolism remains elusive. In this study, we investigat...

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Literature Corpus work: bb0fdc34-53b8-5f16-8a27-3a3d2e8a4f9a
DOI: 10.21203/rs.3.rs-2347974/v1

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