Article
Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation.
Cell reports - 27 Jun 2023
Pathmanapan Sinthu, Poon Raymond, De Renshaw Tomasa Barrientos, Nadesan Puviindran, Nakagawa Makoto, Seesankar Gireesh A, Ho Loe Adrian Kwan, Zhang Hongyuan H, Guinovart Joan J, Duran Jordi, Newgard Christopher B, Wunder Jay S, Alman Benjamin A
Abstract excerpt
Chondrosarcomas are the most common malignancy of cartilage and are associated with somatic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes. Somatic IDH mutations are also found in its benign precursor lesion, enchondromas, suggesting that IDH mutations are early events in malignant transformation. Human mutant IDH chondrosarcomas and mutant Idh mice that develop enchondromas investigated in our...
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