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Glycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer

6 Jun 2023

Abstract excerpt

BACKGROUND: Hypoxia-induced glycogen turnover is implicated in cancer proliferation and therapy resistance. Triple-negative breast cancers (TNBCs), characterized by a hypoxic tumor microenvironment, respond poorly to therapy. We studied the expression of glycogen synthase 1 (GYS1), the key regulator of glycogenesis, and other glycogen-related enzymes in primary tumors of patients with breast cancer and evaluated...

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PMID: 37280675
DOI: 10.1186/s13046-023-02715-z

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