Article

Exploring causal relationships and shared genomic signatures of coronary artery disease and stroke

2025-04-03

Abstract excerpt

Coronary artery disease (CAD) has been shown to be associated with stroke risk. However, the causal genetic overlap and shared genetic architecture underlying CAD and stroke remain unknown. Here, we aim to identify shared genetic relationships between CAD and stroke, focusing on causal genetic overlap, causal directions, and novel risk loci. Using MiXeR, we identified substantial causal variants (∼900) shared betw...

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Literature Corpus work: bb0062d3-b73b-59e6-8931-f00afb2687b1
DOI: 10.1101/2025.04.02.25325075

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