Article
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
Stroke - 1 Jan 2014
Dichgans Martin, Malik Rainer, König Inke R, Rosand Jonathan, Clarke Robert, Gretarsdottir Solveig, Thorleifsson Gudmar, Mitchell Braxton D, Assimes Themistocles L, Levi Christopher, O'Donnell Christopher J, Fornage Myriam, Thorsteinsdottir Unnur, Psaty Bruce M, Hengstenberg Christian, Seshadri Sudha, Erdmann Jeanette, Bis Joshua C, Peters Annette, Boncoraglio Giorgio B, März Winfried, Meschia James F, Kathiresan Sekar, Ikram M Arfan, McPherson Ruth, Stefansson Kari, Sudlow Cathie, Reilly Muredach P, Thompson John R, Sharma Pankaj, Hopewell Jemma C, Chambers John C, Watkins Hugh, Rothwell Peter M, Roberts Robert, Markus Hugh S, Samani Nilesh J, Farrall Martin, Schunkert Heribert
Abstract excerpt
BACKGROUND AND PURPOSE: Ischemic stroke (IS) and coronary artery disease (CAD) share several risk factors and each has a substantial heritability. We conducted a genome-wide analysis to evaluate the extent of shared genetic determination of the two diseases. METHODS: Genome-wide association data were obtained from the METASTROKE, Coronary Artery Disease Genome-wide Replication and Meta-analysis (CARDIoGRAM), and...
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