Article

Synergistic Senolytic–Regenerative Therapy Significantly Extends Healthspan and Lifespan

2026-03-20

Abstract excerpt

<title>Abstract</title> <p>Background Current barriers to achieving radical life extension include the inability to use syngeneic, youthful mesenchymal stem cells (MSCs) and the anti-regenerative effects of senescence-associated secretory phenotype (SASP) factors. We aim to overcome this by a combination approach in which senescent cell burden is reduced utilizing SenoVax™ a dendritic cell based senolytic immuno...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: baff158c-f1d9-5f5c-9fb4-00025cace473
DOI: 10.21203/rs.3.rs-8982528/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Synergistic Senolytic–Regenerative Therapy Significantly Extends Healthspan and LifespanDOI 10.21203/rs.3.rs-8982528/v1Read

Targeting Senescence: A Review of Senolytics and Senomorphics in Anti-Aging InterventionsSemantic proximity Read

Senolytics and Senostatics: A Two-Pronged Approach to Target Cellular Senescence for Delaying Aging and Age-Related Diseases.Semantic proximity Read

Targeting Cellular Senescence for Age-Related Diseases: Path to Clinical TranslationSemantic proximity Read

Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunctionSemantic proximity Read

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span.Semantic proximity Read

Immunotherapeutic approach to reduce senescent cells and alleviate senescence-associated secretory phenotype in mice.Semantic proximity Read

Aging and Mesenchymal Stem Cells: Basic Concepts, Challenges and StrategiesSemantic proximity Read

Senotherapeutics to Counteract Senescent Cells Are Prominent Topics in the Context of Anti-Ageing StrategiesSemantic proximity Read

Senolytic-Resistant Senescent Cells Have a Distinct SASP Profile and Functional Impact: The Path to Developing SenosensitizersSemantic proximity Read

Insights into targeting cellular senescence with senolytic therapy: The journey from preclinical trials to clinical practiceSemantic proximity Read

Combined senolytics induce varied phenotypic and functional responses on senescent phenotypes of mesenchymal stromal cell populations.Semantic proximity Read

Discovery, development, and future application of senolytics: theories and predictions.Semantic proximity Read