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Aging and Mesenchymal Stem Cells: Basic Concepts, Challenges and Strategies

18 Nov 2022

Abstract excerpt

Aging and frailty are complex processes implicating multifactorial mechanisms, such as replicative senescence, oxidative stress, mitochondrial dysfunction, or autophagy disorder. All of these mechanisms drive dramatic changes in the tissue environment, such as senescence-associated secretory phenotype factors and inflamm-aging. Thus, there is a demand for new therapeutic strategies against the devastating effects...

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PMID: 36421393
DOI: 10.3390/biology11111678

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