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Targeting Cellular Senescence for Age-Related Diseases: Path to Clinical Translation

28 Sept 2021

Abstract excerpt

SUMMARY: Beyond the palliative reach of today's medicines, medical therapies of tomorrow aim to treat the root cause of age-related diseases by targeting fundamental aging mechanisms. Pillars of aging include, among others, genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, dysregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 36170432
DOI: 10.1097/prs.0000000000009669

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