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Combined senolytics induce varied phenotypic and functional responses on senescent phenotypes of mesenchymal stromal cell populations.

Biochimie - 1 Aug 2026

Heinrichs David P, Needy Thomas, Maldonado Vitali, Comer Katherine D, Zotti Michael, Berryhill Stuart, Cabrera Ana Regina, Jensen Hanna, Murach Kevin A, Barnes C Lowry, Samsonraj Rebekah M

Abstract excerpt

Mesenchymal stem cells have emerged as a pivotal focus in regenerative medicine and therapeutic innovation due to their multipotent differentiation capacity and immunomodulatory properties. A major obstacle in maintaining human MSC potency and subsequently, the use of MSCs for cellular therapy is replicative senescence, or progressive aging. This obstacle may be alleviated or overcome through the use of...

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Adipogenesis
Cell Differentiation
Cellular Senescence
Dasatinib
Extracellular Vesicles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mesenchymal Stem Cells

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PMID: 42235680
DOI: 10.1016/j.biochi.2026.05.008

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MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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