Article

General Capillary Endothelial Cells Undergo Reprogramming into Arterial Endothelial Cells in Pulmonary Hypertension through HIF-2α/Notch4 Pathway

2024-02-19

Abstract excerpt

Pulmonary arterial hypertension (PAH) is characterized by a progressive increase of pulmonary vascular resistance and obliterative pulmonary vascular remodeling that result in right heart hypertrophy, failure, and premature death. The underlying mechanisms of loss of distal capillary endothelial cells (ECs) and obliterative vascular lesion formation remain unclear. Our recent single-cell RNA sequencing, spatial tr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bafe9506-3dac-584e-8ba5-b11c6fe8f549
DOI: 10.1101/2024.02.13.580227

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

General Capillary Endothelial Cells Undergo Reprogramming into Arterial Endothelial Cells in Pulmonary Hypertension through HIF-2α/Notch4 PathwayDOI 10.1101/2024.02.13.580227Read

Emergence of disease-specific endothelial and stromal cell populations responsible for arterial remodeling during development of pulmonary arterial hypertensionSemantic proximity Read

Single-cell RNA sequencing profiling of mouse endothelial cells in response to pulmonary arterial hypertensionSemantic proximity Read

E2F1 Drives Endothelial Arterial Programming in Pulmonary Arterial HypertensionSemantic proximity Read

Mapping disease-specific vascular cell populations responsible for obliterative arterial remodelling during the development of pulmonary arterial hypertension.Semantic proximity Read

Impaired Capillary Endothelial Cell Differentiation Contributes to pulmonary hypertension in a dynamic Capillary-Alveoli Micro-physiological System and animal modelsSemantic proximity Read

A <i>Tm4sf1</i> -Marked Subpopulation of Endothelial Stem/Progenitor Cells Identified by Lung Single-Cell Omics of Pulmonary Arterial HypertensionSemantic proximity Read

Lung endothelial cell heterogeneity in health and pulmonary vascular diseaseSemantic proximity Read

EBF1 controls an embryonic artery-forming niche that reactivates in pulmonary arterial hypertensionSemantic proximity Read

A Transcriptional Atlas of Endothelial Cell Zonation Along the Pulmonary Vascular TreeSemantic proximity Read

A CXCL12 morphogen gradient uncovers lung endothelial heterogeneity and promotes distal vascular growthSemantic proximity Read

Specialized Pulmonary Vascular Cells in Development and DiseaseSemantic proximity Read

CXCL12 defines lung endothelial heterogeneity and promotes distal vascular growthSemantic proximity Read