Article

EBF1 controls an embryonic artery-forming niche that reactivates in pulmonary arterial hypertension

2025-05-07

Abstract excerpt

Developmental programs that orchestrate cell fate and tissue architecture during organogenesis can cause disease when reactivated in adults. Here we identify a population of endothelial cells (ECs) defined by the pioneer factor early B cell factor 1 (EBF1) that controls both pulmonary artery (PA) morphogenesis and pulmonary arterial hypertension (PAH). During embryonic development, the PA emerges from an endotheli...

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Identifiers and source

Literature Corpus work: 462349da-f1b0-5777-875e-39a68130deca
DOI: 10.1101/2025.05.02.651303

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