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Article

Leveraging effect size distributions to improve polygenic risk scores derived from summary statistics of genome-wide association studies.

PLoS computational biology - 1 Feb 2020

Song Shuang, Jiang Wei, Hou Lin, Zhao Hongyu

Abstract excerpt

Genetic risk prediction is an important problem in human genetics, and accurate prediction can facilitate disease prevention and treatment. Calculating polygenic risk score (PRS) has become widely used due to its simplicity and effectiveness, where only summary statistics from genome-wide association studies are needed in the standard method. Recently, several methods have been proposed to improve standard PRS by...

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PMID: 32045423
DOI: 10.1371/journal.pcbi.1007565
PMCID: PMC7039528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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