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Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neurons

2 Sept 2025

Abstract excerpt

Optineurin (OPTN) is an autophagy adaptor protein involved in selective autophagy, including aggrephagy and mitophagy. Pathogenic mutations in OPTN have also been linked to amyotrophic lateral sclerosis, frontotemporal dementia, and glaucoma, supporting its role in the etiology of neurodegenerative diseases. Despite its established biological roles, knowledge about its potential contribution to Alzheimer's...

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PMID: 40898372
DOI: 10.1186/s40478-025-02103-y

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Optineurin deficiency disrupts phosphorylated tau proteostasis and clusterin expression in human neuronsPMID 40898372Read ↗

Role of Optineurin in the Mitochondrial Dysfunction: Potential Implications in Neurodegenerative Diseases and CancerSemantic proximity Read ↗

Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma.Semantic proximity Read ↗

Fundamental roles of the Optineurin gene in the molecular pathology of Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregatesSemantic proximity Read ↗

The deubiquitinase OTULIN regulates tau expression and RNA metabolism in neuronsSemantic proximity Read ↗

Functional analysis of optineurin and some of its disease-associated mutants.Semantic proximity Read ↗

Emerging views of OPTN (optineurin) function in the autophagic process associated with diseaseSemantic proximity Read ↗

Cellular Functions of Optineurin in Health and Disease.Semantic proximity Read ↗

A yeast model of optineurin proteinopathy reveals a unique aggregation pattern associated with cellular toxicitySemantic proximity Read ↗

Proteomic analysis of aged and OPTN E50K retina in the development of normal tension glaucoma.Semantic proximity Read ↗

CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasisSemantic proximity Read ↗

Optineurin: A Coordinator of Membrane-Associated Cargo Trafficking and Autophagy.Semantic proximity Read ↗

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