Article

Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation

2024-04-22

Abstract excerpt

<title>Abstract</title> <p>Avian influenza A viruses (IAVs) pose a public health threat, as they are capable of triggering pandemics by crossing species barriers. Replication of avian IAVs in mammalian cells is hindered by species-specific variation in acidic nuclear phosphoprotein 32 (ANP32) proteins, which are essential for viral RNA genome replication. Adaptive mutations enable the IAV RNA polymerase (FluPolA)...

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Literature Corpus work: baf8b5cd-50ba-5a52-876e-7af3afd0442a
DOI: 10.21203/rs.3.rs-3716220/v1

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