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Article

Multivalent Dynamic Colocalization of Avian Influenza Polymerase and Nucleoprotein by Intrinsically Disordered ANP32A Reveals the Molecular Basis of Human Adaptation.

Journal of the American Chemical Society - 27 Sept 2023

Camacho-Zarco Aldo R, Yu Lefan, Krischuns Tim, Dedeoglu Selin, Maurin Damien, Bouvignies Guillaume, Crépin Thibaut, Ruigrok Rob W H, Cusack Stephan, Naffakh Nadia, Blackledge Martin

Abstract excerpt

Adaptation of avian influenza RNA polymerase (FluPol) to human cells requires mutations on the 627-NLS domains of the PB2 subunit. The E627K adaptive mutation compensates a 33-amino-acid deletion in the acidic intrinsically disordered domain of the host transcription regulator ANP32A, a deletion that restricts FluPol activity in mammalian cells. The function of ANP32A in the replication transcription complex and...

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PMID: 37707433
DOI: 10.1021/jacs.3c06965
PMCID: PMC10540212

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Multivalent Dynamic Colocalization of Avian Influenza Polymerase and Nucleoprotein by Intrinsically Disordered ANP32A Reveals the Molecular Basis of Human Adaptation.PMID 37707433Read ↗

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