Article

Structures of influenza A and B replication complexes explain avian to human host adaption and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase

2024-04-20

Abstract excerpt

Replication of influenza viral RNA depends on at least two viral polymerases, a parental replicase and an encapsidase, and cellular factor ANP32. ANP32 comprises an LRR domain and a long C-terminal low complexity acidic region (LCAR). Here we show that ANP32 is recruited to the replication complex (replicase-ANP32-encapsidase) by first acting as an electrostatic chaperone to stabilise the encapsidase moiety within...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 91e59dd1-45f4-54ce-93ff-493eaf3eaf1b
DOI: 10.1101/2024.04.20.590211

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structures of influenza A and B replication complexes explain avian to human host adaption and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymeraseDOI 10.1101/2024.04.20.590211Read

Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymeraseSemantic proximity Read

Multivalent dynamic colocalization of avian influenza polymerase and nucleoprotein by intrinsically disordered ANP32A reveals the molecular basis of human adaptationSemantic proximity Read

Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptationSemantic proximity Read

Multivalent Dynamic Colocalization of Avian Influenza Polymerase and Nucleoprotein by Intrinsically Disordered ANP32A Reveals the Molecular Basis of Human Adaptation.Semantic proximity Read

Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptationSemantic proximity Read

The Host Factor ANP32A Is Required for Influenza A Virus vRNA and cRNA Synthesis.Semantic proximity Read

The host factor ANP32A is required for influenza A virus vRNA and cRNA synthesisSemantic proximity Read

ANP32 Proteins Are Essential for Influenza Virus Replication in Human CellsSemantic proximity Read

Fundamental contribution and host range determination of ANP32 protein family in influenza A virus polymerase activitySemantic proximity Read

Avian Influenza A Virus Polymerase Can Utilize Human ANP32 Proteins To Support cRNA but Not vRNA SynthesisSemantic proximity Read

Elucidating the Interactions between Influenza Virus Polymerase and Host Factor ANP32ASemantic proximity Read

Mammalian ANP32A and ANP32B Proteins Drive Differential Polymerase Adaptations in Avian Influenza VirusSemantic proximity Read