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Asp149 and Asp152 in chicken and human ANP32A play an essential role in the interaction with influenza viral polymerase.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jun 2021

Park Young Hyun, Woo Seung Je, Chungu Kelly, Lee Su Bin, Shim Ji Hyeon, Lee Hong Jo, Kim Iktae, Rengaraj Deivendran, Song Chang-Seon, Suh Jeong-Yong, Lim Jeong Mook, Han Jae Yong

Abstract excerpt

The acidic nuclear phosphoprotein 32 family member A (ANP32A) is a cellular host factor that determines the host tropism of the viral polymerase (vPol) of avian influenza viruses (AIVs). Compared with human ANP32A (hANP32A), chicken ANP32A contains an additional 33 amino acid residues (176-208) duplicated from amino acid residues 149-175 (27 residues), suggesting that these residues could be involved in...

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PMID: 33982347
DOI: 10.1096/fj.202002006RR

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