Article

Genome Agnostic Reprogramming of Acute Myelocytic Leukemia Hallmarks by Targeting Non-Oncogene Addictions with Azacitidine plus Pioglitazone and All-Trans Retinoic Acid

2025-12-25

Abstract excerpt

The search for new therapeutic principles is essential for treating relapsed/refractory (r/r) acute myeloid leukemia (AML). Novel principles include genome-agnostic differentiation induction, controlling AML-triggering inflammation, potentiating the immune response and 'normalizing' AML metabolism. This review summarizes data from a phase I study (10 patients, pts) and three case reports (7pts) on the tr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bae58561-e28d-522e-96c4-5fa480489e9d
DOI: 10.20944/preprints202512.2313.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome Agnostic Reprogramming of Acute Myelocytic Leukemia Hallmarks by Targeting Non-Oncogene Addictions with Azacitidine plus Pioglitazone and All-Trans Retinoic AcidDOI 10.20944/preprints202512.2313.v1Read

Acute Promyelocytic Leukemia: Update on the Mechanisms of Leukemogenesis, Resistance and on Innovative Treatment StrategiesSemantic proximity Read

ATRA Resistance in Acute Promyelocytic Leukemia: Mechanisms Unveiled, Therapies ReimaginedSemantic proximity Read

Acute Promyelocytic Leukemia: Update on the Mechanisms of Leukemogenesis, Resistance and on Innovative Treatment StrategiesSemantic proximity Read

Recent advances in acute promyelocytic leukaemiaSemantic proximity Read

Partial differentiation induction of leukemia cells co-opts NK cells to erode leukemic stemnessSemantic proximity Read

Acute promyelocytic leukemia: from highly fatal to highly curableSemantic proximity Read

The Pleiotropic Role of Retinoic Acid/Retinoic Acid Receptors Signaling: From Vitamin A Metabolism to Gene Rearrangements in Acute Promyelocytic LeukemiaSemantic proximity Read

Atypical Rearrangements in APL-Like Acute Myeloid Leukemias: Molecular Characterization and PrognosisSemantic proximity Read

Oncogenic role of RARG rearrangements in acute myeloid leukemia resembling acute promyelocytic leukemiaSemantic proximity Read

Differentiation therapy of acute myeloid leukemia: past, present and futureSemantic proximity Read

Unlocking the potential of retinoic acid in anticancer therapySemantic proximity Read

Current views on the genetic landscape and management of variant acute promyelocytic leukemiaSemantic proximity Read