Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Oncogenic role of RARG rearrangements in acute myeloid leukemia resembling acute promyelocytic leukemia

13 Jan 2025

Abstract excerpt

Acute myeloid leukemia (AML) featuring retinoic acid receptor-gamma (RARG) rearrangements exhibits morphological features resembling those of acute promyelocytic leukemia but is associated with drug resistance and poor clinical outcomes. However, the mechanisms underlying the role of RARG fusions in leukemogenesis remain elusive. Here, we show that RARG fusions disrupt myeloid differentiation and promote...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Protein Degradation and Inhibitors
Share to Retinoids in leukemia and cellular processes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39805831
DOI: 10.1038/s41467-024-55047-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Oncogenic role of RARG rearrangements in acute myeloid leukemia resembling acute promyelocytic leukemiaPMID 39805831Read ↗

RARG Gene Dysregulation in Acute Myeloid LeukemiaSemantic proximity Read ↗

CPSF6-RARγ interacts with histone deacetylase 3 to promote myeloid transformation in RARG-fusion acute myeloid leukemiaSemantic proximity Read ↗

Atypical Rearrangements in APL-Like Acute Myeloid Leukemias: Molecular Characterization and PrognosisSemantic proximity Read ↗

Acute Myeloid Leukemia with NUP98-RARG Gene Fusion Similar to Acute Promyelocytic Leukemia: Case Report and Literature ReviewSemantic proximity Read ↗

The Pleiotropic Role of Retinoic Acid/Retinoic Acid Receptors Signaling: From Vitamin A Metabolism to Gene Rearrangements in Acute Promyelocytic LeukemiaSemantic proximity Read ↗

Acute Promyelocytic Leukemia: Update on the Mechanisms of Leukemogenesis, Resistance and on Innovative Treatment StrategiesSemantic proximity Read ↗

Current views on the genetic landscape and management of variant acute promyelocytic leukemiaSemantic proximity Read ↗

ATRA Resistance in Acute Promyelocytic Leukemia: Mechanisms Unveiled, Therapies ReimaginedSemantic proximity Read ↗

Acute Promyelocytic Leukemia: Update on the Mechanisms of Leukemogenesis, Resistance and on Innovative Treatment StrategiesSemantic proximity Read ↗

Genome Agnostic Reprogramming of Acute Myelocytic Leukemia Hallmarks by Targeting Non-Oncogene Addictions with Azacitidine plus Pioglitazone and All-Trans Retinoic AcidSemantic proximity Read ↗

Recent advances in acute promyelocytic leukaemiaSemantic proximity Read ↗

Critical role of tripartite fusion and LBD truncation in certain RARA- and all RARG-related atypical APLSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.