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Current views on the genetic landscape and management of variant acute promyelocytic leukemia

6 May 2021

Abstract excerpt

Acute promyelocytic leukemia (APL) is characterized by the accumulation of promyelocytes in bone marrow. More than 95% of patients with this disease belong to typical APL, which express PML-RARA and are sensitive to differentiation induction therapy containing all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), and they exhibit an excellent clinical outcome. Compared to typical APL, variant APL showed...

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PMID: 33957999
DOI: 10.1186/s40364-021-00284-x

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